Empowering Hong Kong Chinese families with autism: A preliminary study of the online Hanen More Than Words Program.

Purpose: Parent involvement is crucial for tailored early intervention programs. The Hanen More Than Words (HMTW) program is a parent-implemented language intervention for autistic children. The current study examined the effectiveness of the HMTW program delivered online among Chinese families. Methods: Using a randomized controlled trial design, 22 Chinese families of autistic children in Hong Kong completed the trial. Baseline and post-intervention assessments were conducted to measure changes in parent-child interaction, parents' use of linguistic facilitation techniques (LFTs), and children's communication skills. Additionally, the influence of parental self-efficacy and parenting stress on treatment outcomes was explored. Results: The intervention group demonstrated significant improvements in parent-child attention synchrony. Although the treatment effect on children's spontaneous communication was not significant, the intervention group showed a larger effect size compared to the controls. The treatment outcomes were mainly influenced by the parents' initial levels of self-efficacy but not by parenting stress. Conclusion: These findings provide preliminary evidence of the effectiveness of the online-delivered HMTW program for Chinese parents of autistic children. Further research involving a larger sample and focusing on long-term effects is needed.

Task relevance alters the effect of emotion on congruency judgments during action understanding.

The congruency judgments in action understanding helps individuals make timely adjustments to unexpected occurrence, and this process may be influenced by emotion. Previous research has showed contradictory effect of emotion on conflict processing, possibly due to the degree of relevance between emotion and task. However, to date, no study has systematically manipulated the relevance to explore how emotion affects congruency judgments in action understanding. We employed a cue-target paradigm and controlled the way emotional stimuli were presented on the target interface, setting up three experiments: emotion served as task-irrelevant distractor, task-irrelevant target and task-relevant target. The results showed that when emotion was irrelevant to the task, it impaired congruency judgements performance, regardless of a distractor or a target, while task-relevant emotion facilitated this process. These findings indicate that the impact of emotion on congruency judgements during action understanding depends on the degree of emotion-task relevance.

The relationship between the accuracy of curling athletes' duration judgment and delivery performance.

Objective: Time perception is a critical point for curling athletes to have in order to successfully complete interactions between themselves and their environment. Exploring the relationship between the accuracy of duration judgment and curling athletes' performance is helpful to reveal the influencing factors on their performance and to provide a reference for the training of athletes' delivery performance. Methods: Thirty curling athletes and 30 non-athletes were recruited as participants. Using 3D modeling technology, curling videos of different situations were presented to the participants as stimulus information, and the participants were required to complete the duration judgment task. The neural activation of the participants during the entire process of duration judgment was recorded using electroencephalogram (EEG) equipment. The performance of the 30 curlers participating in the experiment was measured. Variance analyses were conducted on the collected behavioral and EEG data, and correlation and regression analyseswere conducted between behavioral data and delivery performance. Results: The accuracy of the distance judgment of curlers was higher than that of non-curlers (P < 0.05). In the stimulus video presentation stage, the power in the alpha band of curlers was higher than that of non-athletes (P < 0.05). In the task decision stage, the power in the alpha band of curlers was higher than that of non-athletes (P < 0.05), and the power in the theta band was higher than that of non-athletes (P < 0.05). There was a correlation between the accuracy of the curlers' perception of specific situational time intervals and the accuracy of delivery (P < 0.05). Regression analysis results were y = 3.422 + 1.415x. Conclusion: The accuracy of curling athletes' duration judgment is high in a specific situation. There is a correlation between the accuracy of duration judgment and delivery performance in a specific situation: the higher the accuracy of specific duration perception, the higher the performance accuracy of delivery. The cognitive strategies adopted by curlers differ from those adopted by non-athletes in the completion of duration judgment. Specifically, in a specific situation, fewer attention resources are utilized in the stimulus presentation and decision-making stages, while more memory resources are utilized in the decision-making stage to ensure higher accuracy of interval judgment. This study provides a new idea for exploring the causes of curling athletes' excellent technical performance and provides a reference for future curling research on competition training practice. Given the limitations of mobile EEG devices in this study, future studies can measure neural activity during actual delivery preparation and execution in an environment of high ecological validity to obtain more direct evidence.

Expertise influences congruency monitoring during action observation at the motor level.

Congruency monitoring of action occurs in individuals with relevant motor experience while observing actions. However, it remains unclear whether congruency monitoring can occur at the motor level and the extent to which expertise contributes. Here, we examined the behavioral performance and electrophysiological brain activity of individuals with and without domain-specific expertise when judging the action congruency of occluded video clips of a snowboard halfpipe trick and normal walking. For the halfpipe trick, experts exhibited better task performance and greater midline theta oscillations before possible incongruency compared with controls. Source reconstruction for the theta oscillation revealed a stronger activation in the middle and superior frontal gyrus for experts in response to incongruency compared with controls. Incongruent halfpipe actions elicited a higher N400 amplitude in experts compared with congruent actions, while no such differences were observed in controls. Source reconstruction revealed the activation in the board frontal regions and middle temporal gyrus for experts. These findings suggest that congruency monitoring can occur at the motor level during action observations and is modulated by individual expertise. The modulation of expertise reflects in the special N400 effect and midline theta oscillation.

Watching video of discrete maneuvers yields better action memory and greater activation in the middle temporal gyrus in half-pipe snowboarding athletes.

Although motor performance training often involves action observation, it has been controversial whether individual aesthetic sport athletes benefit more from watching videos of discrete maneuvers (DMs) or continuous runs (CRs). In the present study, half-pipe snowboarding athletes completed a visual 2-back task with DM and CR conditions. To explore the neural mechanisms of action memory processing, brain hemodynamic activity during the task was monitored with functional near-infrared spectroscopy (fNIRS). Compared to watching CR videos, watching DM videos tended to yield better action memory performance and greater activation in the middle temporal gyrus to these athletes, suggesting that watching DM videos may have a tendency to improve action memory more effectively. Evidence of two pathways underlying half-pipe snowboarding action processing was obtained. Watching of CR videos and watching of DM videos might be associated with activation of more sensorimotor regions and more semantic regions, respectively, during memory consolidation.

The caveolin-3 P104L mutation in LGMD-1C patients inhibits non-insulin-stimulated glucose metabolism and growth but promotes myocyte proliferation.

The caveolin-3 (CAV3) protein is known to be specifically expressed in various myocytes, and skeletal muscle consumes most of the blood glucose as an energy source to maintain normal cell metabolism and function. The P104L mutation in the coding sequence of the human CAV3 gene leads to autosomal dominant disease limb-girdle muscular dystrophy type 1C (LGMD-1C). We previously reported that C2C12 cells transiently transfected with the P104L CAV3 mutant exhibited decreased glucose uptake and glycogen synthesis after insulin stimulation. The present study aimed to examine whether the P104L mutation affects C2C12 cell glucose metabolism, growth, and proliferation without insulin stimulation. C2C12 cells stably transfected with CAV3-P104L were established, and biochemical assays, western blot analysis and confocal microscopy were used to observe glucose metabolism as well as cell growth and proliferation and to determine the effect of the P104L mutation on the PI3K/Akt signaling pathway. Without insulin stimulation, C2C12 cells stably transfected with the P104L CAV3 mutant exhibited decreased glucose uptake and glycogen synthesis, decreased CAV3 expression and reduced localization of CAV3 and GLUT4 on the cell membrane. The P104L mutant significantly reduced the cell diameters, but accelerated cell proliferation. Akt phosphorylation was inhibited, and protein expression of GLUT4, p-GSK3ß, and p-p70s6K, which are molecules downstream of Akt, was significantly decreased. The CAV3-P104L mutation inhibits glycometabolism and cell growth but accelerates C2C12 cell proliferation by reducing CAV3 protein expression and cell membrane localization, which may contribute to the pathogenesis of LGMD-1C.